Why it is important study quiescent cancer stem cells Essay

Why it is important study quiescent cancer stem cells - Essay Example The study done by Dembinski and Krauss (2009) gave a profound evidence of linkages between quiescence and cancer stem cells. Moreover, the study of quiescence CSCs is important for the reason that the quiescent cancer stem cells are found to be resistant to chemotherapy and other applied therapies (Moore 2010). It has been discovered that as soon as the therapy is discontinued, they retain their state. In this perspective, it becomes necessary to understand the mechanisms of stem cell quiescent state so that normal stem cell functionality could be manipulated. The understanding on this account helps develop the clinical approaches to quell and target cancer stem cells. As per Li (2011), the recent findings explain the resistance of cancer stem cells by their state of dormancy. Dormant cancer stem cells can be activated by altering their intrinsic or extrinsic mechanisms that tend to maintain their quiescent state so that they become susceptible to the applied chemotherapy and help discover new visions in the cancer treatment. From above it is quite clear that the study of quiescence CSCs is likely to open new vistas in the discovery of new cancer drugs and therapies to get effective and lasting treatment for all kinds of cancers. 1. Moore N.; Lyle, S. (2010),Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance, Online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948913/#sec6 [Accessed 23 October 2011] 3. Roesch A, Fukunaga-Kalabis M, et al (2010). A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell., 141(4):583–594. Also online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882693/ [Accessed 23 October 2011] 4. Dembinski JL, Krauss S. (2009), Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma, Clinical and Experimental Metastasis, 26 (7):611–623.

The Link Between Productiveness And Motivation Essay

The Link Between Productiveness And Motivation - Essay Example Some things that happen in life come as surprise and bring happiness while some others happen and cause serious distress because their outcome is a loss of an important aspect of life. In case of the issues that happen in the life of a person, how that person responds to it becomes an important way because it enhances his or her participation in the society. In the same way, a person may have various opportunities within his or her capability but the choice to participate in any of them should not be influenced by what other people may have an opinion about it but rather what he or she feels is the best thing to do. This means that a person needs to do something he or she will be passionate so that he will be able to be productive even without motivation from other people. Neil Pasricha presents a talk about The Three A’s of Awesome in which he describes the need for exploration of the opportunities that are available to a person to make life good. In some instances, he uses t he example of the things that happened to his family when his father and mother started living in Toronto in the late 1960s in their mid-twenties and how his sister and he grew to be mature individuals. Pasricha narrates how the early life his sister and he lived was with little care about the things that were otherwise important to his parents and how they perceived the different things that they experienced. He narrates how some of the things in his life shaped his life through triggering a sense of happiness and others triggered a lot of pain in his life. Pasricha faced the effects of the economic meltdown that happened in 2008 and 2009 and he had to suffer other things but later he did the things that he liked the most in his life and it brought a lot of benefit to him. He made a blog site that he observed grow from just a single reader to an award-winning blog that was attracting millions of readers from all over the world.